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. 2021 Nov 29;16(3):397–419. doi: 10.1007/s12079-021-00646-y

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Fig. 4 — CD47 and TSP1 regulation of m⁷G-cap-dependent mRNA trafficking in human and murine T cells. a GSEA analysis shows enrichment of EIF4E-dependent RNAs in EVs released from CD47⁻ versus WT Jurkat T cells. b Venn Diagram representing overlap between CD47-dependent mRNAs in cells and EVs with previously reported EIF4E-dependent capped RNAs (Culjkovic-Kraljacic et al. 2016). c, d Expression of YOD1, EEFIA1 and ETS1 mRNAs in untreated WT and CD47⁻ Jurkat T cells and cells treated with TSP1 or LMB. EVs were isolated using Exo-spin™ technology. e Expression of Yod1, Eefia1 and Ets1 in control, and LMB or TSP1 treated WT and Cd47^−/− mouse T cells using total cellular RNA. f–j Cytosolic and nuclear mRNA expression of YOD1, EEFIA1, CUL7, ETS1 and XPO1 in untreated WT and CD47⁻ Jurkat T cells and cells treated with 1 μg/ml TSP1. p < 0.05 (*), p < 0.01 (**), p < 0.001 (***)