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. 2022 Aug 25;13:5010. doi: 10.1038/s41467-022-32742-x

Fig. 3. SUB-EC, SUB-MMB, and SUB-NAc circuits function differently in modulating hippocampal seizures.

Fig. 3

a Scheme of experiments and a representative sagittal image for Arch-eGFP expression in the subiculum (SUB) and light stimulation in the entorhinal cortex (EC). Scale bar, 100 μm. b Effects of optogenetic inhibition of SUB-EC circuit on the development of seizure stage and after-discharge durations (ADD). Two-way repeated measures ANOVA, *P < 0.05. c, d Effects of optogenetic inhibition of SUB-EC circuit on the ADD (c) and generalized seizure durations (GSD, d) during sGS expression. One-way repeated measures ANOVA with post hoc Dunnett’s test, *P < 0.05 compared to Pre. **P < 0.01 compared to Pre. e Representative CA3 EEGs and power spectrogram during sGSs. f Scheme of experiments and a representative coronal image for Arch-eGFP expression in the subiculum (SUB) and light stimulation in the in the mamillary bodies (MMB) or nucleus accumbens (NAc). Scale bar, 100 μm. g Effects of optogenetic inhibition of SUB-MMB and SUB-NAc circuits on the development of seizure stage and ADD. The number of mice used in each group is indicated in figure. Data are presented as means ± SEM.