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. 2022 Aug 25;13:5010. doi: 10.1038/s41467-022-32742-x

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© The Author(s) 2022

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — a Scheme and representative image of in vivo recording in distinct layers of the subiculum (SUB). Scale bar, 100 μm. b Typical firing rate of bursting units in the SUBa and SUBb. Each subjacent triangle indicates a defined bursting. Graphs of average firing rate (c) and burst per minute (d) of bursting units in the SUBa and SUBb in the basal state. Unpaired t-test, **P < 0.01. e Scheme of in vitro electrophysiological patch in the somata of ANT-projecting and non-ANT-projecting subicular neurons and one representative ANT-projecting subicular neuron. Scale bar, 10 μm. f Statistics of number of ANT-projecting and non-ANT-projecting burst and regular firing neurons. g Left, representative voltage traces and current from patched neurons. Right, graph of the sag ratio between ANT-projecting and non-ANT-projecting bursting and regular firing neurons, n = 16, 9, 16, 11, respectively. One-way ANOVA with post hoc Tukey’s test, *P < 0.05, ***P < 0.001, ****P < 0.0001. h I_h voltage-dependent activation curves between ANT-projecting and non-ANT-projecting neurons. Both curves fitted with Boltzmann function. Two-way repeated measures ANOVA, **P < 0.01. i Representative action potentials of ANT-projecting and non-ANT-projecting subicular bursting neurons evoked by −200 and100 pA injection current. j Graphs of action potential number and frequency on burst between ANT-projecting and non-ANT-projecting subicular bursting neurons. Mann–Whitney test, *P < 0.05, **P < 0.01. k Representative action potentials in one subicular bursting neuron before and after incubation of 20 μM HCN channel blocker, ZD7288. Graph of action potential number on burst (l) and rest membrane potential (m) before and after ZD7288 buffering. Wilcoxon matched-pairs signed rank test for AP number on burst, *P < 0.05. Paired t test for RMP, *P < 0.05. The number of mice used in each group is indicated in the figure. Data are presented as means ± SEM.