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. 2022 Aug 12;13:918476. doi: 10.3389/fimmu.2022.918476

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Copyright © 2022 Chen, Wang, Xie, Liu, Liao, Shi, Chen, Lai, Wang and Wu

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Effects of Rg5 on PAF or LPS-induced release of NETs and inflammatory factors in WT or P2RY₁₂-KO neutrophils. (A) Effect of Rg5 on WT or P2RY₁₂-KO neutrophils viability (n = 4). (B, C) Immunofluorescent staining and statistical analysis of CitH3 in WT or P2RY₁₂-KO neutrophils stimulated by PAF or LPS. (n = 6). (D, E) DNA concentration (n = 4) and IL-6, IL-1β, and TNF-α concentrations (n = 4) in the medium of WT or P2RY₁₂-KO neutrophils stimulated by PAF or LPS. All the data are shown as the mean ± SEM. *P < 0.05, **P < 0.01, ***P < 0.001 vs. PAF or LPS group.