Fig. 2. Associations between polygenic risk for coronary artery disease (CAD) and self-reported history, collected at baseline and throughout follow-up in the Women’s Health Initiative.

Associations for three analyses are compared. ‘All’ shows associations in the main study cohort. ‘All CAD adjusted’ shows associations in the main study cohort with adjustment for presence/absence of CAD at last follow-up. ‘No CAD’ shows associations among the subset of participants with no CAD at last follow-up. Only outcomes with at least 100 cases in the CAD-free group were considered (128 outcomes). The plot shows all outcomes that were significant with FDR q-value ≤ 0.05 in any of the three analyses. Error bars represent 95% confidence intervals. The number of cases and controls for each test is included in the Self-reported outcomes section of the Supplementary Data.