Fig. 3. Associations between polygenic risk for coronary artery disease and incident adjudicated cardiovascular diseases in the Women’s Health Initiative.

Outcomes with at least 100 incident cases were considered. Models were adjusted for smoking status, self-reported diabetes at baseline, systolic blood pressure, low-density lipoprotein cholesterol, and high-density lipoprotein cholesterol. Odds ratios (OR) are per 1 standard deviation increase in polygenic risk score. Error bars represent 95% confidence intervals. Outcomes with a single asterisk are significant with an FDR q-value ≤ 0.05. Outcomes with double asterisks have a Bonferroni significant p-value 0.003 (0.05/17). PTCA = Percutaneous Transluminal Coronary Angioplasty; CABG = Coronary Artery Bypass Graft; ASCVD = Atherosclerotic Cardiovascular Disease; TIA = Transient Ischemic Attack