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. 2022 Aug 12;13:906043. doi: 10.3389/fphar.2022.906043

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Copyright © 2022 Wang, Otkur, Wang, Wang, Lyu, Fang, Shan, Song, Feng, Zhao, Piao, Qi and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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NCTD inhibited Vem-induced upregulation of PPP based on CE-MS metabolomics analysis. (A,B) Intersection of many sets of metabolites revealed, especially downregulating and upregulating metabolites of NCTD in A375R cells. (C) Heatmap of significantly changed metabolites based on CE-MS in the A375, A375R, A375 + NCTD, and A375R + NCTD samples. Red in the heatmap represented the upregulated metabolites, and blue represented downregulated metabolites. (D) Six histograms showed statistically significantly downregulated metabolites in A375R cells.