TABLE 2.

Target the gut microbiota that produces TMA or its TMA lyase.

Selectively target	Result	Mechanism	References
3,3-dimethyl-1-butanol (DMB)	Decreased TMAO	DMB non-lethally suppresses microbial CutC/D	Wang et al. (2015)
Iodomethylcholine (IMC)	Decreased TMA and TMAO	IMC and FMC selectively target inhibition of choline TMA lyase activity of the gut microbiota	Robert et al. (2018)
Fluoromethylcholine (FMC)			Gupta et al. (2020)
Iodomethylcholine (IMC)	Decreased TMAO level	IMC non-lethal inhibit choline TMA lyase activity	Zhang et al. (2021)