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Compounds that inhibit FMO3 activity.
| FMO3 inhibitor | Results | Mechanism | References |
|---|---|---|---|
| Thiamazole | Decreased TMAO level, increased TMA level | Thiamazole is classic substrate and competitive inhibitor of FMO3 | Schweifer and Barlow (1996) |
| 3,3′-Diindolylmethane | Decreased TMAO level | 3,3′-Diindolylmethane inhibits FMO3 | Chen et al. (2019) |
| Cashman et al. (1999) | |||
| Consuming indole | Decreased the relative ratio of TMAO to TMA | Consuming indole competitively inhibits FMO3 | Steinke et al. (2020) |
