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. 2022 Aug 12;13:955459. doi: 10.3389/fmicb.2022.955459

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Copyright © 2022 Chi, Wang, Ji, Li, Zhu, Yan, Fu, Zou and Ren.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Quorum sensing system in Staphylococcus aureus and the interference of natural products on quorum sensing system. AgrD is the precursor of autoinducer peptides (AIP). AIP can be modified by AgrB and secreted into the matrix. AIP secreted by bacteria accumulates in the environment and binds to kinase receptors (AgrC) on the bacterial membrane to transmit signals, activating the related genes’ expression, such as RNAII and RNAIII. RNAIII regulates most QS-related genes, while some genes are controlled by AgrA directly. Emodin inhibited AgrA gene expression and luteolin interfered Agr system.