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. 2022 Aug 12;13:955459. doi: 10.3389/fmicb.2022.955459

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Copyright © 2022 Chi, Wang, Ji, Li, Zhu, Yan, Fu, Zou and Ren.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Quorum sensing system in P. aeruginosa and the interference of natural products on quorum sensing system. There are three key pathways in the P. aeruginosa QS system: two LuxI/LuxR-type QS pathways and the pseudomonas quinolone signal (PQS) system, named Las, rhl, and pqs. The synthesis of AI’s 3-oxo-C12-HSL and C4-HSL is modulated by Las and Rhl, which serve as their autoinducers, respectively. In addition, alkyl-4-quinolones (AQs), including PQS and HHQ, are signal molecules in the PQS pathway. Interconnections between the three pathways regulate the activity of the QS system, resulting in changes in cell adhesive proteins, virulence factors, biofilm formation and proteases. Quercetin inhibited LasI, LasR, RhlI, RhlR gene expression and baicalin inhibited Pqs system.