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. 2022 Aug 12;9:962685. doi: 10.3389/fvets.2022.962685

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Copyright © 2022 Sabattini, Rigillo, Foiani, Marconato, Vascellari, Greco, Agnoli, Annoni, Melchiotti, Campigli, Benali and Bettini.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Dog, spleen. Main histologic characteristics observed in splenic nodules with mixed stromal, histiocytic and lymphoid components. (A) CD20 immunohistochemistry (IHC): positivity of lymphocytes arranged in follicles and of fewer diffusely-distributed lymphocytes. (B) CD3 IHC: positivity of the diffuse lymphoid infiltrate. (C) Hematoxylin and eosin (HE): spindle cells with nuclear atypia and plasma cell infiltrate. (D) HE: stromal, histiocytic and lymphoid components irregularly admixed. (E) Same field after desmin IHC, highlighting stromal cells. (F) Same field after CD18 IHC, highlighting histiocytic cells. (G) HE: cells displaying karyomegaly. (H) Desmin IHC: strong cytoplasmic positivity of karyomegalic cells. (I) CD18 IHC: diffuse negativity of karyomegalic cells.