Table 2.
Univariable Cox regression analysis of variables potentially associated with an increased risk of disease-related death in 37 dogs with mixed stromal, histiocytic and lymphoid splenic nodular lesions.
| Variable | Hazard ratio | 95% CI | P -value |
|---|---|---|---|
| Age ≥ 10 years | 4.29 | 0.84–22.01 | 0.081 |
| Male sex | 1.80 | 0.42–7.73 | 0.428 |
| Neutering | 0.25 | 0.03–2.04 | 0.196 |
| Body weight ≥ 15 kg | 0.80 | 0.21–3.00 | 0.743 |
| Clinical signs at presentation | 3.72 | 0.45–30.57 | 0.222 |
| Palpable abdominal mass | 1.95 | 0.38–10.13 | 0.426 |
| Anemia | 2.54 | 0.27–23.58 | 0.412 |
| Neutrophilia | 4.29 | 0.81–22.69 | 0.087 |
| Thrombocytopenia | 5.16 | 0.72–37.22 | 0.103 |
| Thrombocytosis | 0.70 | 0.70–6.96 | 0.760 |
| Decreased A/G ratio | 0.64 | 0.10–4.08 | 0.637 |
| Splenic nodule rupture | 1.91 | 0.42–8.78 | 0.406 |
| Nodule diameter ≥ 6 cm | 8.45 | 1.03–69.67 | 0.047* |
| Poor demarcation of nodule | 1.99 | 0.49–7.99 | 0.334 |
| Lymphoid component <40% | 4.25 | 1.13–15.93 | 0.032* |
| Diffuse distribution of lymphoid component | 73.32 | 0.34–1586.97 | 0.117 |
| Spindle cells with nuclear atypia | 10.64 | 1.32–85.68 | 0.026* |
| Karyomegaly | 4.43 | 1.02–19.20 | 0.047* |
| Multinucleated cells | 17.02 | 3.16–91.76 | 0.001* |
| MC ≥ 9 | 10.93 | 2.26–52.98 | 0.003* |
| Necrosis >10% | 86.22 | 0.38–197.78 | 0.108 |
| Thrombosis | 5.57 | 1.15–26.92 | 0.032* |
*
Significant at the 5% level. CI, confidence interval; A/G, albumin to globulin; MC, mitotic count.