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The synopsis of the main trend topics.
| (1) Major clinical studies show baclofen as a treatment for alcohol dependence is still premature. |
| (2) Biomarkers such as gut microbial fingerprint, DNA methylation in GABA receptor genes, and blood metabolites have been identified for alcohol use disorder. |
| (3) Abnormal glial cell functions are promising neuropathology for alcohol use disorder. |
| (4) Females are more likely to develop alcohol use disorder. |
