Table 3.

The association of prescription of methotrexate and folic acid with COVID-19-related death in the UK Biobank

	Unadjusted		Model 1		Model 2
	OR, (95% CI)	P value	OR, (95% CI)	P value	OR, (95% CI)	P value
Neither folic acid nor methotrexate, N=363 821	1.0	–	1.0	–	1.0	–
Folic acid only, N=12 433	5.14 (4.23 to 6.24)	<0.001	2.91 (2.38 to 3.55)	<0.001	2.64 (2.15 to 3.24)	<0.001
Methotrexate and folic acid, N=3952	1.47 (0.81 to 2.67)	0.21	1.26 (0.70 to 2.30)	0.44	1.07 (0.57 to 1.98)	0.84

Model 1 adjusted for age group, sex, ethnicity, Townsend deprivation index, body mass index, smoking status.

Model 2 is model 1 plus adjustment by the presence of rheumatoid arthritis, sickle cell disease, use of statins, anticonvulsants and iron supplementation.

*There were no deaths in the group of participants taking only methotrexate without folate.