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. 2022 Jul 13;189(1):124–147. doi: 10.1093/toxsci/kfac068

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© The Author(s) 2022. Published by Oxford University Press on behalf of the Society of Toxicology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 1. — Schematic of the systemic safety toolbox and associated workflow, which comprises 3 modules: one to estimate the exposure using physiologically based kinetic (PBK) models, another to estimate the point of departure (POD) based on the cell stress panel (CSP), high throughput transcriptomics (HTTr), and in vitro pharmacological profiling (IPP) bioactivity data. The workflow involves combining the outputs from these 2 modules into the third module to estimate the bioactivity exposure ratio (BER).