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. 2022 Jul 13;189(1):124–147. doi: 10.1093/toxsci/kfac068

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© The Author(s) 2022. Published by Oxford University Press on behalf of the Society of Toxicology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 4. — Overview of platform PODs (in vitro pharmacological profiling—IPP, cell stress panel, and high-throughput transcriptomics—HTTr) obtained using the toolbox for each of benchmark chemicals. High-throughput transcriptomics data were generated for 3 cell lines (MCF7, HepaRG, HepG2) and analyzed using 2 different methods (BMDexpress and BIFROST), resulting 6 transcriptomics platform PODs per chemical. Positive controls for the transcriptomics platform (Tunicamycin and Trichostatin A) are also included.