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. 2022 Jul 13;189(1):124–147. doi: 10.1093/toxsci/kfac068

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© The Author(s) 2022. Published by Oxford University Press on behalf of the Society of Toxicology.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Figure 7. — A, Summary of the iterative approach for evaluating and then refining the toolbox beyond the current version (ie, version 1). B, Overview of current toolbox version and potential improvements for future iterations. Abbreviations: iPSC, induced pluripotent stem cell; AUC, area under curve; CSS, steady-state concentration; BER, bioactivity exposure ratio; CMED, C_max error distribution; PBK, physiologically based kinetic; HTTr, high-throughput transcriptomics; CSP, cell stress panel; IPP, in vitro pharmacological profiling; POD, point of departure.