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. 2022 Jul 13;189(1):124–147. doi: 10.1093/toxsci/kfac068

Table 3.

Summary of Prototype Decision Model

PBK Level Threshold BER Required for Exposure to Be Identified as Low Risk Confidence Threshold (pthreshold) Required for Exposure Scenario to Be Identified as Low Risk Probability of Overturning Low-Risk Decision at Next PBK Level Empirical Utility Empirical Protectiveness
1 110 .98 .1 3/18 (17%) 6/6 (100%)
2 11 .97 .1 6/18 (33%) 6/6 (100%)
3 2.5 .95 9/13 (69%) 5/5 (100%)