Table 4.

Spearman Correlation between adverse events and immunogenicity after the first and the second vaccines adjusted for age, gender, and days after vaccination.

	Anti-IgG-RBD				Neutralizing AB
	After 1st Vaccination		After 2nd Vaccination		After 1st Vaccination		After 2nd Vaccination
N	233		733		89		118
	R	p	R	p	R	p	R	p
Score of systemic AEs	0.1	0.13	0.366	<0.0001	−0.1	0.34	0.283	0.005
Axillary lymphadenopathy	−0.018	0.78	0.15	<0.0001	NA		0.1	0.28
Fever	0.12	0.7	0.19	<0.0001	−0.2	0.057	0.13	0.15
Fatigue	0.1	0.12	0.18	<0.0001	−0.08	0.46	0.18	0.04
Headache	0.07	0.04	0.19	<0.0001	0.08	0.45	0.12	0.18
Myalgia	0.14	0.3	0.21	<0.0001	0.017	0.87	0.2	0.03
Arthralgia	0.09	0.15	0.135	<0.05	0.003	0.97	0.03	0.7
Need for antipyretic or analgetic medication	0.078	0.24	0.197	<0.0001	−0.12	0.25	−0.16	0.07
Missing workdays	0.06	0.36	0.11	0.0027	NA		0.06	0.4