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. 2022 Aug 13;10(8):472. doi: 10.3390/toxics10080472

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Metal transporters and receptors involved in cadmium reabsorption. (a) Metal transporters and receptors in the kidney tubule; (b) receptor-mediated endocytosis of filtered proteins. Reabsorption of Cd and CdMT by kidney tubular epithelial cells are mediated by multiple transporter systems such as the megalin/cubilin and NGAL/lipocalin 2 systems and transporters for zinc (Zn), iron (Fe), calcium (Ca) and manganese (Mn).