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. 2022 Aug 6;14(8):1643. doi: 10.3390/pharmaceutics14081643

Table 1.

Independent and dependent variables in Box Behnken design for preparation and optimization of Qu-PMMs.

Factors Levels
Independent Variable Low (−1) Centre (0) High (+1)
A = Soluplus (mg mL−1) 10 15 20
B = E-TPGS (mg mL−1) 0.1 0.5 1.0
C = Poloxamer 407 (% w/v) 0.1 0.2 0.3
Dependent variable Goals
Y1 = PS (nm) Decrease
Y2 = PDI Decrease
Y3 = EE (%) Increase
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