Table 1.
Independent and dependent variables in Box Behnken design for preparation and optimization of Qu-PMMs.
Factors | Levels | ||
---|---|---|---|
Independent Variable | Low (−1) | Centre (0) | High (+1) |
A = Soluplus (mg mL−1) | 10 | 15 | 20 |
B = E-TPGS (mg mL−1) | 0.1 | 0.5 | 1.0 |
C = Poloxamer 407 (% w/v) | 0.1 | 0.2 | 0.3 |
Dependent variable | Goals | ||
Y1 = PS (nm) | Decrease | ||
Y2 = PDI | Decrease | ||
Y3 = EE (%) | Increase |