Table 2.
Minimum inhibitory concentrations (MICs) of econazole against four strains associated with fungal keratitis, the concentration required in the cornea to attain MIC, the concentration of econazole localised in the cornea after 6 h (n = 3 ± SD) and factor (based on a corneal volume of 0.19 mL).
| Fungal Strain |
Fusarium
semitectum |
Fusarium
solani |
Scolecobasidium
tshawytschae |
Bipolaris
hawaiiensis |
|---|---|---|---|---|
| Mean MIC [econazole], μg/mL | 141 | 141 | 283 | 283 |
| [Econazole] required in cornea (MIC×0.19), μg | 26.79 | 26.79 | 53.77 | 53.77 |
| [Econazole] in cornea, @ 6h; econazole only eyedrop | 21.66 ± 2.36 | 21.66 ± 2.36 | 21.66 ± 2.36 | 21.66 ± 2.36 |
| Factor, [econazole] delivered/MIC×0.19 | ×0.81 | ×0.81 | ×0.40 | ×0.40 |
| [Econazole] in cornea, @ 6h; econazole contact lens | 90.88 ± 9.75 | 90.88 ± 9.75 | 90.88 ± 9.75 | 90.88 ± 9.75 |
| Factor, [econazole] delivered/MIC×0.19 | ×3.39 | ×3.39 | ×1.69 | ×1.69 |
| [Econazole] in cornea, @ 6h; econazole + HP-β-CD eyedrop | 60.57 ± 11.47 | 60.57 ± 11.47 | 60.57 ± 11.47 | 60.57 ± 11.47 |
| Factor, [econazole] delivered/MIC×0.19 | ×2.26 | ×2.26 | ×1.13 | ×1.13 |
| [Econazole] in cornea, @ 6h; econazole + HP-β-CD contact lens | 160.17 ± 23.63 | 160.17 ± 23.63 | 160.17 ± 23.63 | 160.17 ± 23.63 |
| Factor, [econazole] delivered/MIC×0.19 | ×5.98 | ×5.98 | ×2.98 | ×2.98 |
| [Econazole] in cornea, @ 6h; econazole + HP-α-CD eyedrop | 87.65 ± 8.74 | 87.65 ± 8.74 | 87.65 ± 8.74 | 87.65 ± 8.74 |
| Factor, [econazole] delivered/MIC×0.19 | ×3.27 | ×3.27 | ×1.63 | ×1.63 |
| [Econazole] in cornea, @ 6h; econazole + HP-α-CD contact lens | 200.8 ± 9.6 | 200.8 ± 9.6 | 200.8 ± 9.6 | 200.8 ± 9.6 |
| Factor, [econazole] delivered/MIC×0.19 | ×7.5 | ×7.5 | ×3.73 | ×3.73 |