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. 2022 Aug 12;14(16):3314. doi: 10.3390/nu14163314

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Effect of ANA-12 on the antidepressant effect and active stress coping response induced by L7Gn in sleep-deprived mice. L7Gn was dissolved in 70% PEG-saline, and ANA-12 was dissolved in 1% DMSO. Mice were administered vehicle (70% PEG), L7Gn (3 mg/kg), or ANA-12 (0.5 mg/kg) once daily for four–five days, followed by the (A) TST and (B) FST. (A) TST: (one-way ANOVA: F (3, 24) = 3.873, p = 0.0217) (B) FST: (one-way ANOVA: F (3, 22) = 8.152, p = 0.0008). Data are presented as mean ± SEM (n = 6–8/group). * p < 0.05, significantly different from the control group. # p < 0.05, significantly different from the vehicle group. $ p < 0.05, significantly different from the L7Gn (3 mg/kg) group. CTL, control; Veh, vehicle.