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Schematic illustration of the effect of increased ROS production on Bcl-2 protein, MMP, caspase activity and intrinsic apoptotic pathway activation. ROS = Reactive oxygen species; MMP = Mitochondrial membrane potential; cyt-c = Cytochrome c; Apaf1 = Apoptotic peptidase activating factor 1; 
= Overproduction; 
= Down regulation; 
= Activation.
