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. 2022 Aug 17;27(16):5252. doi: 10.3390/molecules27165252

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© 2022 by the author.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Scheme of cyclophosphamide (CP) activation and drug reaction with GSH [74]. Possible GSH S-conjugates: 1: 4-monoglutathionyl cyclophosphamide, 2: monoglutathionyl phosphoramide mustard, 3: diglutathionyl phosphoramide mustard. 4-OH-CP = 4-hydroxycyclophosphamide; APA = aldophosphamide; PAM = phosphoramide mustard; P450 = cytochrome P450. Predicted bioactive sites of GSH conjugation for anticancer drug were obtained by XenoSite Reactivity Predictor available at https://swami.wustl.edu/xenosite/p/reactivity (accessed on 18 May 2022).