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. 2022 Aug 17;27(16):5252. doi: 10.3390/molecules27165252

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© 2022 by the author.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Cisplatin (cis-DDP) bioactivation through GSH S-conjugate (Pt-GSH) and cysteine S-conjugate (Pt-Cys) formation [18,52]. cis-DDP = cisplatin; GSH = glutathione; GST = glutathione S-transferase; γ-GT = γ-glutamyl transferase; Pt = platinum (II) aqua species.