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Formation of reactive busulfan metabolites in a GSH-dependent pathway [170]. EdAG = γ-glutamyl-dehydroalanyl-glycine; GSG = EdAG-GSH S-conjugate; GSH = glutathione; GST = glutathione S-transferase; GS-THT+ = glutathionyl-tetrahydrothiophene; THT = tetrahydrothiophene.
