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(A) Azathioprine [174] and (B) sulofenur [181] bioactivation to anticancer-active metabolites by GST-mediated GSH conjugation. 6-MP = 6-mercaptopurine; CPIC = p-chlorophenyl isocyanate; GSH = glutathione; GST = glutathione S-transferase; NACC = N-acetyl-S-(p-chlorophenylcarbamoyl) cysteine; SCPG = S-(N-p-chlorophenylcarbamoyl) GSH.
