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Design ideas a of PROTACs. (A) Design ideas of PROTACs. Using S3I-201 analog and pomalidomide as ligands, a series of STAT3 PROTACs were designed by changing Linker. (B) Docking model of pomalidomide binding to CRBN (PDB:4CI3). Pomalidomide is colored by atom type and CRBN is represented in cartoon form. Critical residues are shown as sticks. Hydrogen bonds are represented by yellow dashed lines.
