Table 1.
Comparison laboratory parameters between dead and improved patients infected with COVID-19
| Variables | dead patients (n = 495) | Improved patients (n = 497) | P-value |
|---|---|---|---|
| Mean age ± SD | 62.6 ± 11.9 | 51.1 ± 11.8 | 0.515 |
| Gender (male/female) | 259/236 (52.3/47.7%) | 270/227 (54.3/45.7%) | 0.527 |
| ALT, IU/L (mean ± SD) (Reference range: 5–40) | 32.6 ± 19.5 | 31.2 ± 20.1 | 0.144 |
| AST, IU/L (mean ± SD) (Reference range: 5–40) | 33.9 ± 18.2 | 30.8 ± 17.4 | 0.064 |
| ALP, IU/L (mean ± SD) (Reference range: up to 306) | 178.7 ± 81.4 | 163.9 ± 79.4 | 0.073 |
| Cholesterol, mg/dL (mean ± SD) (Reference range: 50–200) | 116.1 ± 46.4 | 128.5 ± 51.2 | < 0.001* |
| TG, mg/dL (mean ± SD) (Reference range: 60–165) | 128.7 ± 59.8 | 137.1 ± 61.2 | 0.025* |
| LDL, mg/dL (mean ± SD) (Reference range: up to 150) | 62.3 ± 29.7 | 95.4 ± 48.2 | < 0.001* |
| HDL, mg/dL (mean ± SD) (Reference range: > 40) | 32.1 ± 11.9 | 34.4 ± 12.5 | 0.813 |
| WBC, 109/L (mean ± SD) (Reference range: 4000–10,000) | 7553.0 ± 2680.1 | 7773.5 ± 2865.9 | 0.245 |
| CRP, mg/L (mean ± SD) (Reference range: < 10 mg/L Negative) | 70.1 ± 21.4 | 51.9 ± 19.2 | < 0.001* |
| ESR, mm/1st h (mean ± SD) (Reference range: 0–15) | 56.3 ± 15.7 | 45.9 ± 15.1 | < 0.001* |
| FBS, mg/dL (mean ± SD) (Reference range: 70–100) | 106.8 ± 41.5 | 107.2 ± 42.1 | 0.806 |
| Platelets × 1000/cumm (mean ± SD) (Reference range: 140,000–400,000) | 185 ± 77 | 183 ± 68 | 0.577 |
| T3, ng/dL (mean ± SD) (Reference range: 2.3–4.2) | 3.5 ± 1.6 | 2.7 ± 1.3 | 0.066 |
| T4, mcg/dL (mean ± SD) (Reference range: 5.6–13.7) | 9.1 ± 6.8 | 8.4 ± 6.3 | 0.128 |
| TSH, mu/L (mean ± SD) (Reference range: 0.4–4.5) | 3.4 ± 2.1 | 3.1 ± 1.7 | 0.808 |
| Hemoglobin, g/dL (mean ± SD) (Reference range: 12–18) | 14.2 ± 2.2 | 12.8 ± 1.5 | 0.378 |
| BUN, mg/dL (mean ± SD) (Reference range: 15–45) | 39.2 ± 6.2 | 38.1 ± 7.1 | 0.527 |
| Creatinine, mg/dL (mean ± SD) (Reference range: 0.6–1.4) | 1.5 ± 0.7 | 0.9 ± 0.3 | 0.107 |
| 25-hydroxy vitamin D, ng/mL (mean ± SD) (Sufficiency: 21–150) | 19.4 ± 9.2 | 40.2 ± 12.8 | < 0.001* |
| Real-time PCR Ct values | 12.4 ± 6.2 | 29.1 ± 9.3 | 0.010* |
| TRIM22 rs1063303 | |||
| CC genotype | 69 (13.9%) | 197 (39.6%) | < 0.001* |
| GC genotype | 258 (52.2%) | 224 (45.1%) | |
| GG genotype | 168 (33.9%) | 76 (15.3%) | |
| TRIM22 rs7935564 | |||
| AA genotype | 89 (18.0%) | 261 (52.5%) | < 0.001* |
| AG genotype | 159 (32.1%) | 186 (37.4%) | |
| GG genotype | 247 (49.9%) | 50 (10.1%) | |
| TRIM22 rs7113258 | |||
| AA genotype | 109 (22.0%) | 294 (59.2%) | < 0.001* |
| AT genotype | 159 (32.1%) | 151 (30.4%) | |
| TT genotype | 227 (45.9%) | 52 (10.4%) | |
ALT alanine aminotransferase; AST aspartate aminotransferase; ALP alkaline phosphatase; TG triglyceride; LDL low-density lipoprotein; HDL high-density lipoprotein; WBC white blood cells; CRP C-reactive protein; ESR erythrocyte sedimentation rate; FBS fasting blood glucose; T3 triiodothyronine; T4 thyroxine; TSH Thyroid-stimulating hormone; BUN Blood urea nitrogen; Ct cycle threshold; SD standard deviation
*Statistically significant (< 0.05)