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. 2022 Aug 1;14(8):1606. doi: 10.3390/pharmaceutics14081606

Figure 4.

Figure 4

Pgp-siRNAsome@Dox.HCl for synergistic therapy against drug-resistant cancer. Reprinted with permission from Ref. [109]. 2019, Wiley. (a) Schematic diagram of the mechanism of Pgp-siRNAsome@Dox.HCl surmounting cancer drug resistance. (b) Dox.HCl release from Pgp-siRNAsome@Dox.HCl. (c) Cellular uptake of Pgp-siRNAsome@Dox.HCl. (d) Gene silencing of Pgp mRNA level in MDR MCF-7 cells. ** p < 0.01. (e) In vitro cytotoxicity against MDR MCF-7 cells. ** p < 0.01. (f) In vivo antitumor effect of Pgp-siRNAsome@Dox.HCl. ** p < 0.01, *** p < 0.001.