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. 2022 Aug 1;14(8):1606. doi: 10.3390/pharmaceutics14081606

Figure 6.

Figure 6

CP@NP-cRGD for overcoming cancer drug resistance. Reprinted with permission from Ref. [188]. 2020, Wiley. (a) Diagram of CP@NP-cRGD intracellular mechanisms of overcoming drug resistance. (b) In vitro release curve of CP@NP-cRGD. (c) Cellular uptake of RB-loaded CP@NP-cRGD in AZD9291-resistant cells. ** p < 0.01, *** p < 0.001. (d) The lysosomal escape of CP@NP-cRGD. (e) Antitumor molecular mechanisms of CP@NP-cRGD. (f) CP@NP-cRGD inhibited autophagy of H1975/AR cells. *** p < 0.001. (g) In vivo antitumor efficiency of CP@NP-cRGD. * p < 0.05, ** p < 0.01, *** p < 0.001.