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. 2022 Aug 1;14(8):1606. doi: 10.3390/pharmaceutics14081606

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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T12/P-Lipo for overcoming cancer drug resistance and brain metastases. Reprinted with permission from Ref. [215]. 2020, NIH. (a) The targeting receptors in BCECs. (b) Uptake of T12/P-Lipo by H1975 cells. (c) Fluorescence images of T12/P-Lipo in H1975 cells. (d) Macrophage repolarization from M2 to M1. (e) The level of NOX3/MsrA/GPX4/Bcl-2 in H1975 cells. (f) The level of phosphorylated EGFR/p-Akt/p-Erk. (g) The level of cleaved caspase 3. (h) The survival curves. (i) Tumor regression after treatment with T12/P-Lipo. * p < 0.05.