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. 2022 Aug 1;14(8):1606. doi: 10.3390/pharmaceutics14081606

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© 2022 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

PMC Copyright notice

Schematic diagram of synergistic effect of immunochemotherapy by a microneedle patch containing aPD-1/CDDP@NPs. Reprinted with permission from Ref. [258]. 2020, Royal Society of Chemistry. (a) The mechanism of enhanced immunotherapy induced by aPD-1/CDDP@NP MNs. (b) SEM images of dissolving microneedles. (c) Fluorescence microscopy image of the microneedles. (d) Antitumor efficacy in vivo. *** p < 0.001. (e) The positive rate of CD4+ T cells. * p < 0.05. (f) The positive rate of CD8+ T cells. * p < 0.05. (g) IFN-γ expression in the serum. ** p < 0.01. (h) The percentages of CD4+FOXP3+ Tregs. * p < 0.05.