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. 2022 Aug 12;9:859787. doi: 10.3389/fmolb.2022.859787

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Copyright © 2022 Bayram, Razzaque, Geisberger, Pietzke, Fürst, Vechiatto, Forbes, Mastrobuoni and Kempa.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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¹⁵N Enrichment in AMP/GMP (purine nucleotides) in HEK293, HCT116 and RKO cells. Cells were cultivated with ¹³C₅-glutamate and ¹⁵N-ammonium for 24 h. Nucleotide isotopologues were measured via direct-infusion MS and relative quantities are graphically represented. Data represent mean ± SD of three biological replicates.