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Milestones in ancient protein mass spectrometry. The broadest applications of protein mass spectrometry in archaeology today are ZooMS (zooarchaeology by mass spectrometry), which applies MALDI-TOF MS peptide mass fingerprinting to collagens, keratins, and other high abundance proteins (left), and shotgun proteomics, which uses high-resolution LC–MS/MS to identify diverse, low abundance proteins in complex mixtures (right).
