Table 1.
Baseline characteristics of hemodialysis patients according to their anti-spike IgG antibody response at day 28.
| Variables | All (n = 206) | Nonresponders (n = 68) | Responders (n = 138) |
p Value |
|---|---|---|---|---|
| Demographic data | ||||
| Age (year) | 66.9 ± 12.5 | 72.5 ± 10.9 | 64.1 ± 12.4 | <0.001 |
| Male sex, n (%) | 104 (50.5%) | 37 (54.4%) | 67 (48.6%) | 0.429 |
| Smoking history, n (%) | 39 (18.9%) | 15 (22.1%) | 24 (17.4%) | 0.421 |
| Dialysis vintage (year) | 8.4 ± 5.8 | 9.3 ± 6.6 | 7.9 ± 5.3 | 0.102 |
| Kt/V | 1.7 ± 0.3 | 1.7 ± 0.3 | 1.7 ± 0.2 | 0.391 |
| URR (%) | 75.9 ± 5.4 | 76.2 ± 6.7 | 75.8 ± 4.7 | 0.618 |
| nPCR (g/kg/day) | 1.07 (0.92–1.24) | 1.05 (0.91–1.16) | 1.09 (0.93–1.27) | 0.106 |
| Body mass index (kg/m2) | 23.4 ± 3.8 | 22.6 ± 4.1 | 23.8 ± 3.6 | 0.032 |
| Diabetes mellitus, n (%) | 112 (54.4%) | 42 (61.8%) | 70 (50.7%) | 0.135 |
| Hypertension, n (%) | 186 (90.3%) | 62 (91.2%) | 124 (89.9%) | 0.763 |
| CAD, n (%) | 52 (25.2%) | 27 (39.7%) | 25 (18.1%) | 0.001 |
| Stroke, n (%) | 8 (3.9%) | 4 (5.9%) | 4 (2.9%) | 0.297 |
| Malignancy, n (%) | 24 (11.7%) | 10 (14.7%) | 14 (10.1%) | 0.337 |
| Use of IS, n (%) | 5 (2.4%) | 4 (5.9%) | 1 (0.7%) | 0.024 |
| Laboratory data | ||||
| Albumin (g/dL) | 3.8 (3.6–4.0) | 3.7 (3.5–4.0) | 3.9 (3.7–4.0) | 0.073 |
| Fasting glucose (mg/dL) | 143 (114–192) | 151 (125–201) | 138 (114–191) | 0.221 |
| Lymphocyte (×109/L) | 1.1 (0.9–1.4) | 1.0 (0.7–1.2) | 1.2 (1.0–1.5) | <0.001 |
| Hemoglobin (g/dL) | 10.4 (9.5–11.0) | 10.4 (9.3–11.2) | 10.4 (9.6–11.0) | 0.707 |
| Ferritin (ng/mL) | 461 (250–644) | 443 (279–645) | 474 (225–644) | 0.868 |
| Calcium (mg/dL) | 9.4 (8.8–10.0) | 9.4 (8.8–10.0) | 9.4 (8.9–10.1) | 0.432 |
| Phosphate (mg/dL) | 4.4 (3.6–5.3) | 4.2 (3.6–5.6) | 4.5 (3.7–5.2) | 0.691 |
| iPTH (pg/mL) | 326 (140–593) | 348 (126–600) | 326 (141–593) | 0.931 |
CAD = coronary artery disease; iPTH = intact parathyroid hormone; IS = immunosuppressant; nPCR = normalized protein catabolic rate; URR = urea reduction ratio.