Table 4.
Solicited local and systemic reactions as determinants of anti-spike IgG antibody response to SARS-CoV-2 vaccination.
| Variables | Univariate | Multivariate | ||
|---|---|---|---|---|
| OR (95% CI) | p Value | OR (95% CI) | p Value | |
| Local reaction | 2.27 (1.20–4.28) | 0.012 | 2.11 (0.98–4.54) | 0.056 |
| Pain | 2.08 (1.10–3.92) | 0.024 | 1.92 (0.89–4.13) | 0.096 |
| Redness | 1.95 (0.62–6.12) | 0.252 | 2.48 (0.61–10.10) | 0.205 |
| Swelling | 2.14 (0.77–5.96) | 0.147 | 1.72 (0.49–6.04) | 0.399 |
| Systemic reaction | 2.10 (1.16–3.79) | 0.014 | 1.60 (0.79–3.23) | 0.193 |
| Fatigue | 1.83 (0.93–3.58) | 0.080 | 1.74 (0.79–3.85) | 0.169 |
| Headache | 2.12 (0.87–5.15) | 0.097 | 1.32 (0.46–3.85) | 0.606 |
| Muscle and joint pain | 2.49 (1.13–5.51) | 0.024 | 1.43 (0.54–3.75) | 0.471 |
| Nausea or vomiting | 1.49 (0.15–14.59) | 0.732 | 2.54 (0.11–58.71) | 0.564 |
| Abdominal pain | 1.33 (0.34–5.19) | 0.678 | 1.78 (0.34–9.31) | 0.494 |
| Diarrhea | 3.14 (0.68–14.46) | 0.141 | 4.03 (0.59–27.35) | 0.154 |
| Fever | 2.85 (1.37–5.94) | 0.005 | 2.70 (1.12–6.50) | 0.026 |
| Symptom score (per one increase) | 1.37 (1.13–1.66) | 0.002 | 1.33 (1.05–1.68) | 0.019 |
OR = odds ratio. Adjusted for age, sex, body mass index, diabetes mellitus, coronary artery disease, use of immunosuppressant, albumin, and lymphocyte count.