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Impact of P-gp inhibition of the brain kinetics of [11C]domperidone compared to [11C]metoclopramide. Time-activity curves (TAC) were obtained with [11C]metoclopramide (A,B) and [11C]-domperidone (C,D) in the absence and presence of P-gp inhibitor tariquidar (TQD). (A,C) present the raw data in the brain, while (B,D) are the corresponding plasma TAC curves corrected from metabolism exposures. Data are reported as mean ± S.D with n = 4 per brain condition and n = 2 per plasma condition.
