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. 2022 Aug 12;13:953206. doi: 10.3389/fphys.2022.953206

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Copyright © 2022 Sharawy, Imam, Aboulhoda, Khalifa, Morcos, Abd Algaleel, Moustafa, Abdelbaset and Shoukry.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Altered cognitive, behavioral and motor coordination functions with sepsis. Murine sepsis score (MSS) (A) is significantly-induced by CLP. CLP decreased the percentage of the novel object exploration time (B), the time spent on the rotarod (C), and the locomotor activity (D) at 6, 24, and 72 h post-sepsis. The time for contact with (E) and removal of (F) the tape was significantly increased at 24 and 72 h after CLP. An asymmetrical motor behavior could not be observed after the elevated body swing test (G). Data are the means ± SEM. *p < 0.05 vs. the corresponding sham group; !p < 0.05 vs. the 6 h CLP group; and ^# p < 0.05 vs. the 24 h CLP group. N = 10 rats per group.