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. 2022 Aug 12;13:953206. doi: 10.3389/fphys.2022.953206

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Copyright © 2022 Sharawy, Imam, Aboulhoda, Khalifa, Morcos, Abd Algaleel, Moustafa, Abdelbaset and Shoukry.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Linear regression analysis between brain iron levels and pro-inflammatory macrophage (M1) polarization markers. Significant positive correlation is noticed between the brain iron levels and the pro-inflammatory markers: iNOS (A) and iNOS/Arg-1 ratio (B). Significant negative correlation is noted between brain iron level and the anti-inflammatory markers Arg-1 (C) and FIZZ (D).