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. 2022 Aug 12;13:953206. doi: 10.3389/fphys.2022.953206

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Copyright © 2022 Sharawy, Imam, Aboulhoda, Khalifa, Morcos, Abd Algaleel, Moustafa, Abdelbaset and Shoukry.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Changes in serum transferrin and brain ferritin over time during sepsis. The quantitative analysis of brain ferritin (A) and serum transferrin (B) showed a significant decrease in brain ferritin level, but not in serum transferrin, at 24 and 72 h after sepsis. (C) Pearson’s correlation analysis between iron level in the brain and ferritin level. The serum iron level (D), the total iron binding capacity (TIBC) (E), the plasma transferrin (F), and the percentage of transferrin saturation (G) are not significantly different between the sham- and CLP-operated groups. Data are the means ± SEM. *p < 0.05 vs. the corresponding sham group; !p < 0.05 vs. the 6-h CLP group; ^# p < 0.05 vs. the 24-h CLP group. N = 10 rats per group.