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. 2022 Aug 12;13:953206. doi: 10.3389/fphys.2022.953206

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Copyright © 2022 Sharawy, Imam, Aboulhoda, Khalifa, Morcos, Abd Algaleel, Moustafa, Abdelbaset and Shoukry.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Transferrin- and non-transferrin-bound iron-uptake gene expression in the brain during sepsis. (A–D) Quantitative real-time reverse-transcription polymerase chain reaction analysis of the transferrin receptor protein 1 (TfR-1) (A), cubilin (B), the divalent metal transporter 1 (DMT-1) (C), and the brain zinc transporters (ZIP) (D). The expression levels of transferrin-bound iron transporters (TBI) (TfR-1(A) and cubilin (B)) in the brain during sepsis were not altered, whereas sepsis increased the expression of NTBI transporters (DMT-1(C) and ZIP (D)). (E–G) Pearson’s correlation analysis between the iron level in the brain and the DMT-1 (E) the ZIP (F) and the TfR-1 (G). Data are the means ± SEM. *p < 0.05 vs. the corresponding sham group; !p < 0.05 vs. the 6 h CLP group; ^# p < 0.05 vs. the 24 h CLP group. N = 10 rats per group.