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Advantages and limitations of different preclinical models for anticancer drug testing; (A) patient derived models, (B) non patient-derived animal models. GEMM, genetically engineered mouse model; GVHD, graft versus host disease; nGEMM, non-germinal genetically engineered mouse model; PDX, patient-derived xenograft; TEC, tumor explant culture; TME, tumor microenvironment; 2D, bi-dimensional; TSC, tumor slice culture.
