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. 2022 Aug 24;10(8):e004880. doi: 10.1136/jitc-2022-004880

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© Author(s) (or their employer(s)) 2022. Re-use permitted under CC BY. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution 4.0 Unported (CC BY 4.0) license, which permits others to copy, redistribute, remix, transform and build upon this work for any purpose, provided the original work is properly cited, a link to the licence is given, and indication of whether changes were made. See https://creativecommons.org/licenses/by/4.0/.

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BCG and Zol combinatorial treatment boost circulating and urinary Vδ2 T-cell functions from NMIBC patients. Evaluation of cytotoxic capacity (CD107a) and cytokines (IFN-γ and TNF-α) production of (A) circulating (n=6) and (B) urinary (n=5) Vδ2 T cells from NMIBC patients on coculture with J82 and Bu68.08 cell lines treated with the combination of BCG and Zol. Indicated p values were determined by one-way ANOVA, comparing each condition with control (black stars) or combined treatment (black hash). (C) Determination of urinary Vδ2 T-cell polyfunctionality on coculture with BCa cell lines treated with BCG and Zol combined treatment. * or ^# p<0.05. ** or ^##p<0.01. *** or ^###p<0.001. **** or ^#### p<0.0001. ANOVA, analysis of variance; NMIBC, non-muscle-invasive bladder cancer.