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Synthesis of the curcumin analogs C1–C6. Reagents and conditions: (f) chloromethyl ethyl ether, DIEA, CH2Cl2, 12 h; (g) aqueous NaOH, ethanol, 48 h; (h) concentrated hydrochloric acid, methanol, 12 h; (i) SOCl2, 80 °C, reflux, 2 h; (j) CHCl3, triethylamine, 0 °C to room temperature, 12 h.
