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. Author manuscript; available in PMC: 2023 Sep 1.
Published in final edited form as: Addict Biol. 2022 Sep;27(5):e13222. doi: 10.1111/adb.13222

Figure 1. Breeding scheme of the Four Core Genotypes (FCG) mice.

Figure 1.

Breeding XX (wild-type) females with a XY/Sry+ mice results in four groups of offspring. XX/Sry− and XY/Sry− mice have ovaries and secrete female levels of hormones regardless of chromosome complement. XX/Sry+ and XY/Sry+ mice have testes and secrete male levels of hormones regardless of chromosome complement. Key: Purple chromosomes: mouse X chromosomes; gray chromosomes: mouse Y chromosomes; for Sry− mice the female mouse reproductive system is shown and for Sry+ mice the male mouse reproductive system is shown. The reproductive systems consist of gonadal (ovaries or testes) and non-gonadal tissues.