Figure 5.

The antinociceptive effect of (+)-2R/S-LP2 was antagonized by PRE-084 pre-treatment. Subcutaneous administration of PRE-084 hydrochloride (32 mg/kg) 20 min before (+)-2R/S-LP2 reverted its effect in the second phase of the formalin test. Results are expressed as mean ± SEM (n = 6–8 per group) and are represented as the percentage of inhibition of pain responses of the respective vehicle group (100%). ° p < 0.05 vs. (+)-2R/S-LP2, * p < 0.05 vs. Vehicle, two-way ANOVA followed by Bonferroni post-hoc test.