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. 2022 Aug 12;16(8):11815–11832. doi: 10.1021/acsnano.1c10034

Figure 8.

Figure 8

Comparison of downregulated nanoconjugate permeation in ADtg-brain with upregulated nanoconjugate permeation in tumor and with low BBB permeation in normal mice. (A) BBB-permeation efficacies (in terms of fluorescence intensity) in cortex of ADtg-brain (5XFAD) at dose 2X is significantly reduced in comparison with the cortex of the normal brain (BL/6 mice) for P/LLL/AP2, P/LLL/D3, P/LLL/B6, and P/LLL(40%). (B) Comparison of normal mice at a dose of 2X with tumor-bearing mice at dose of 1X. Error bars represent SEM.